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PTGX Protagonist Therapeutics, Inc

Trailing twelve months to 2026-06-30 · as filed 2026-08-05, not restated
Healthcare

Scale

Market cap
$9.7bn
Revenue TTM
$282m
Net income TTM
$83m
Free cash flow
$131m
Composite score
48.2
Sector rank
#730

Valuation

P / E
117.2
EV / EBITDA
149.2
EV / sales
31.7
FCF yield
1.34%
Earnings yield vs 10-yr
-3.88pp

Earnings yield vs 10-yr compares what the business earns per pound invested against the 4.73% a 10-year US Treasury note pays for no equity risk. Negative means you are paying up front for growth not yet delivered.

Quality and growth

Net margin
29.4%
EBITDA margin
21.2%
ROE
9.8%
ROIC
98.9%
Revenue growth
34.8%

Insider activity, last 90 days

Net open-market
$-17.82m
Buyers
0
Sellers
2

Open-market purchases and sales only. Grants, option exercises, gifts and shares withheld for tax are excluded: they are how people are paid, not what they think.

What management said

We are eligible to receive up to $580.0 million in future development and sales milestone payments, including the following potential milestones: We will also receive upward tiered royalties on net worldwide ICOTYDE product sales at percentages ranging from 6% to 10%. Our weighted-average royalty rate on the first $4.0 billion in annual net sales is 7.25%, and the rate on net sales over $4.0 billion is 10%. Following the opt-out, Takeda has an exclusive worldwide license to develop and commercialize rusfertide, and we are eligible to receive tiered royalties ranging from 14% to 29% on annual worldwide net sales, with an approximate weighted-average royalty rate of 21% at $1.5 billion in annu …Protagonist Therapeutics, Inc, 10-Q, period ended 2026-06-30, filed 2026-08-05

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