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SEPN Septerna, Inc.

Trailing twelve months to 2026-06-30 · as filed 2026-08-10, not restated
Healthcare

Scale

Market cap
$1.9bn
Revenue TTM
$99m
Net income TTM
$-24m
Free cash flow
$105m
Composite score
Sector rank
#1673

Valuation

P / E
EV / EBITDA
EV / sales
15.4
FCF yield
5.55%
Earnings yield vs 10-yr
-6.01pp

Earnings yield vs 10-yr compares what the business earns per pound invested against the 4.73% a 10-year US Treasury note pays for no equity risk. Negative means you are paying up front for growth not yet delivered.

Quality and growth

Net margin
-24.5%
EBITDA margin
-42.4%
ROE
-6.3%
ROIC
-302.4%
Revenue growth

Insider activity, last 90 days

Net open-market
$-73.32m
Buyers
0
Sellers
5

Open-market purchases and sales only. Grants, option exercises, gifts and shares withheld for tax are excluded: they are how people are paid, not what they think.

What management said

We have incurred and will continue to incur significant increased costs as a result of operating as a public company, and our management is required to devote substantial time to new compliance initiatives and corporate governance practices.Septerna, Inc., 10-Q, period ended 2026-06-30, filed 2026-08-10

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